Melasma is a common hyperpigmentation disorder, characterized by\nlight-to-dark brown patches, usually distributed on sun-exposed areas of the body. The objective of\nthis study was to evaluate the efficacy and tolerability of an oral nutritional supplement containing\nPinus pinaster and Grape seed extract, vitamins and minerals, used concomitantly with a high SPF\nsunscreen in 30 women with mild-to-moderate facial melasma. Methods: Efficacy was assessed by\nmeasurement of the Melasma Area and Severity Index (MASI), instrumental analysis of the lesions\n(Mexameter®, VISIA®)) and Patientâ??s and Physicianâ??s Global Assessment (PGA). Results: The MASI\nscore decreased significantly compared with baseline at days 28, 56, and 84. Mexameter® analysis\nshowed a significant decrease of Delta M (difference in the melanin index between melasma and adjacent\narea). VISIA® results also showed a reduction in the number and areas of UV pigmented spots and\nin the areas of melasma overtime. Both the Patientâ??s and Physicianâ??s Global Assessment showed\nthat the product led to an improvement of the lesions in terms of depigmentation and had positive\ncosmetic features without adverse events. Conclusion: The oral supplement subject of this study\nin combination with high SPF sunscreen was effective and well-tolerated for treatment of mild to\nmoderate facial melasma.
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